Results by Title
15 books about Pharmacology
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Adrenaline
Brian B. Hoffman
Harvard University Press, 2013
Library of Congress QP572.A27H64 2013 | Dewey Decimal 616.45
Inducing highs of excitement, anger, and terror, adrenaline fuels the extremes of human experience. A rush empowers superhuman feats in emergencies. Risk-taking junkies seek to replicate this feeling in dangerous recreations. And a surge may literally scare us to death. Adrenaline brings us up to speed on the fascinating molecule that drives some of our most potent experiences.
Adrenaline was discovered in 1894 and quickly made its way out of the lab into clinics around the world. In this engrossing account, Brian Hoffman examines adrenaline in all its capacities, from a vital regulator of physiological functions to the subject of Nobel Prize–winning breakthroughs. Because its biochemical pathways are prototypical, adrenaline has had widespread application in hormone research leading to the development of powerful new drugs. Hoffman introduces the scientists to whom we owe our understanding, tracing the paths of their discoveries and aspirations and allowing us to appreciate the crucial role adrenaline has played in pushing modern medicine forward.
Hoffman also investigates the vivid, at times lurid, place adrenaline occupies in the popular imagination, where accounts of its life-giving and lethal properties often leave the realm of fact. Famous as the catalyst of the “fight or flight” response, adrenaline has also received forensic attention as a perfect poison, untraceable in the bloodstream—and rumors persist of its power to revive the dead. True to the spirit of its topic, Adrenaline is a stimulating journey that reveals the truth behind adrenaline’s scientific importance and enduring popular appeal.
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Children and Drug Safety: Balancing Risk and Protection in Twentieth-Century America
Connolly, Cynthia A
Rutgers University Press, 2018
Library of Congress RJ560.C66 2018 | Dewey Decimal 615.1083
Winner of the 2018 Arthur J. Viseltear Award from the Medical Care Section of the American Public Health Association
Children and Drug Safety traces the development, use, and marketing of drugs for children in the twentieth century, a history that sits at the interface of the state, business, health care providers, parents, and children. This book illuminates the historical dimension of a clinical and policy issue with great contemporary significance—many of the drugs administered to children today have never been tested for safety and efficacy in the pediatric population.
Each chapter of Children and Drug Safety engages with major turning points in pediatric drug development; themes of children’s risk, rights, protection and the evolving context of childhood; child-rearing; and family life in ways freighted with nuances of race, class, and gender. Cynthia A. Connolly charts the numerous attempts by Congress, the Food and Drug Administration, the American Academy of Pediatrics, and leading pediatric pharmacologists, scientists, clinicians, and parents to address a situation that all found untenable.
Open access edition funded by the National Endowment for the Humanities.
The text of this book is licensed under a Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International License: https://creativecommons.org/licenses/by-nc-nd/4.0/
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The Cult of Pharmacology: How America Became the World's Most Troubled Drug Culture
Richard DeGrandpre
Duke University Press, 2006
Library of Congress RM263.D44 2006 | Dewey Decimal 615.1
America had a radically different relationship with drugs a century ago. Drug prohibitions were few, and while alcohol was considered a menace, the public regularly consumed substances that are widely demonized today. Heroin was marketed by Bayer Pharmaceuticals, and marijuana was available as a tincture of cannabis sold by Parke Davis and Company. Exploring how this rather benign relationship with psychoactive drugs was transformed into one of confusion and chaos, The Cult of Pharmacology tells the dramatic story of how, as one legal drug after another fell from grace, new pharmaceutical substances took their place. Whether Valium or OxyContin at the pharmacy, cocaine or meth purchased on the street, or alcohol and tobacco from the corner store, drugs and drug use proliferated in twentieth-century America despite an escalating war on “drugs.” Richard DeGrandpre, a past fellow of the National Institute on Drug Abuse and author of the best-selling book Ritalin Nation, delivers a remarkably original interpretation of drugs by examining the seductive but ill-fated belief that they are chemically predestined to be either good or evil. He argues that the determination to treat the medically sanctioned use of drugs such as Miltown or Seconal separately from the illicit use of substances like heroin or ecstasy has blinded America to how drugs are transformed by the manner in which a culture deals with them. Bringing forth a wealth of scientific research showing the powerful influence of social and psychological factors on how the brain is affected by drugs, DeGrandpre demonstrates that psychoactive substances are not angels or demons irrespective of why, how, or by whom they are used. The Cult of Pharmacology is a bold and necessary new account of America’s complex relationship with drugs.
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Healing and Society in Medieval England: A Middle English Translation of the Pharmaceutical Writings of Gilbertus Anglicus
Faye M. Getz
University of Wisconsin Press, 1991
Library of Congress R487.G55313G48 1991 | Dewey Decimal 610.9420902
Originally composed in Latin by Gilbertus Anglicus (Gilbert the Englishman), his Compendium of Medicine was a primary text of the medical revolution in thirteenth-century Europe. Composed mainly of medicinal recipes, it offered advice on diagnosis, medicinal preparation, and prognosis. In the fifteenth-century it was translated into Middle English to accommodate a widening audience for learning and medical “secrets.”
Faye Marie Getz provides a critical edition of the Middle English text, with an extensive introduction to the learned, practical, and social components of medieval medicine and a summary of the text in modern English. Getz also draws on both the Latin and Middle English texts to create an extensive glossary of little-known Middle English pharmaceutical and medical vocabulary.
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Iatrogenicity: Causes and Consequences of Iatrogenesis in Cardiovascular Medicine
Gussak, Ihor B
Rutgers University Press, 2017
Library of Congress RC671 | Dewey Decimal 616.1
Iatrogenesis is the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one’s expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors. This is a huge public health issue: tens to hundreds of thousands of deaths are attributed to iatrogenic causes each year in the U.S., and vulnerable populations such as the elderly and minorities are particularly susceptible.
Edited by two renowned cardiology experts, Iatrogenicity: Causes and Consequences of Iatrogenesis in Cardiovascular Medicine addresses both the iatrogenicity that arises with cardiovascular interventions, as well as non-cardiovascular interventions that result in adverse consequences on the cardiovascular system. The book aims to achieve three things: to summarize the available information on this topic in a single high-yield volume; to highlight the human and financial cost of iatrogenesis; and to describe and propose potential interventions to ameliorate the effects of iatrogenesis. This accessible book is a practical reference for any practicing physician who sees patients with cardiovascular issues. .
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Jungle Laboratories: Mexican Peasants, National Projects, and the Making of the Pill
Gabriela Soto Laveaga
Duke University Press, 2009
Library of Congress HD9670.M62S68 2009 | Dewey Decimal 338.47615324
In the 1940s chemists discovered that barbasco, a wild yam indigenous to Mexico, could be used to mass-produce synthetic steroid hormones. Barbasco spurred the development of new drugs, including cortisone and the first viable oral contraceptives, and positioned Mexico as a major player in the global pharmaceutical industry. Yet few people today are aware of Mexico’s role in achieving these advances in modern medicine. In Jungle Laboratories, Gabriela Soto Laveaga reconstructs the story of how rural yam pickers, international pharmaceutical companies, and the Mexican state collaborated and collided over the barbasco. By so doing, she sheds important light on a crucial period in Mexican history and challenges us to reconsider who can produce science. Soto Laveaga traces the political, economic, and scientific development of the global barbasco industry from its emergence in the 1940s, through its appropriation by a populist Mexican state in 1970, to its obsolescence in the mid-1990s. She focuses primarily on the rural southern region of Tuxtepec, Oaxaca, where the yam grew most freely and where scientists relied on local, indigenous knowledge to cultivate and harvest the plant. Rural Mexicans, at first unaware of the pharmaceutical and financial value of barbasco, later acquired and deployed scientific knowledge to negotiate with pharmaceutical companies, lobby the Mexican government, and ultimately transform how urban Mexicans perceived them. By illuminating how the yam made its way from the jungles of Mexico, to domestic and foreign scientific laboratories where it was transformed into pills, to the medicine cabinets of millions of women across the globe, Jungle Laboratories urges us to recognize the ways that Mexican peasants attained social and political legitimacy in the twentieth century, and positions Latin America as a major producer of scientific knowledge.
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Medical Monopoly: Intellectual Property Rights and the Origins of the Modern Pharmaceutical Industry
Joseph M. Gabriel
University of Chicago Press, 2014
Library of Congress RA401.A3G33 2014 | Dewey Decimal 338.476151
During most of the nineteenth century, physicians and pharmacists alike considered medical patenting and the use of trademarks by drug manufacturers unethical forms of monopoly; physicians who prescribed patented drugs could be, and were, ostracized from the medical community. In the decades following the Civil War, however, complex changes in patent and trademark law intersected with the changing sensibilities of both physicians and pharmacists to make intellectual property rights in drug manufacturing scientifically and ethically legitimate. By World War I, patented and trademarked drugs had become essential to the practice of good medicine, aiding in the rise of the American pharmaceutical industry and forever altering the course of medicine.
Drawing on a wealth of previously unused archival material, Medical Monopoly combines legal, medical, and business history to offer a sweeping new interpretation of the origins of the complex and often troubling relationship between the pharmaceutical industry and medical practice today. Joseph M. Gabriel provides the first detailed history of patent and trademark law as it relates to the nineteenth-century pharmaceutical industry as well as a unique interpretation of medical ethics, therapeutic reform, and the efforts to regulate the market in pharmaceuticals before World War I. His book will be of interest not only to historians of medicine and science and intellectual property scholars but also to anyone following contemporary debates about the pharmaceutical industry, the patenting of scientific discoveries, and the role of advertising in the marketplace.
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Medicating Children: ADHD and Pediatric Mental Health
Rick Mayes, Catherine Bagwell, and Jennifer Erkulwater
Harvard University Press, 2009
Library of Congress RJ506.H9M4234 2009 | Dewey Decimal 362.198928589
Why and how did ADHD become the most commonly diagnosed mental disorder among children and adolescents, as well as one of the most controversial? Stimulant medication had been used to treat excessively hyperactive children since the 1950s. And the behaviors that today might lead to an ADHD diagnosis had been observed since the early 1930s as “organic drivenness,” and then by various other names throughout the decades.Rick Mayes and colleagues argue that a unique alignment of social and economic trends and incentives converged in the early 1990s with greater scientific knowledge to make ADHD the most prevalent pediatric mental disorder. New movements advocating for the rights of children and the disabled and a massive increase in Medicaid spending on psychotropic drugs all contributed to the dramatic spike in ADHD diagnoses and stimulant use. Medicating Children is unique in that it integrates analyses of the clinical, political, historical, educational, social, economic, and legal aspects of ADHD and stimulant pharmacotherapy. Thus, it will be invaluable to educators, clinicians, parents, and policymakers, all of whom are trying to determine what is in the best interest of millions of children.
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Neuropharmacotherapy in Critical Illness
Brophy, Gretchen
Rutgers University Press, 2017
Library of Congress RC387.5.N4757 2018 | Dewey Decimal 617.481061
The field of research related to neurocritical care has grown significantly in recent years, and the clinical demands for current and dependable expertise has followed suit. It can be a challenge for the neurocritical practitioner to keep up with cutting-edge evidence-based research and best practices, especially regarding the role of pharmacotherapeutics.
In the treatment of neurocritical disease states, pharmacotherapeutic strategies are increasingly relevant. Neuropharmacotherapy in Critical Illness is the first book that provides this information in a high-yield format for the busy healthcare provider. Edited and authored by leading experts in the field, this book provides practitioners with clinical pearls on neuropharmacology, dosing strategies, monitoring, adverse events, drug interactions, and evidence-based pharmacotherapy.
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Physical and Biophysical Foundations of Pharmacy Practice: Issues in Drug Delivery
Gordon L. Flynn, Michael S. Roberts
Michigan Publishing Services, 2015
Focused on the physical and biological barriers and opportunities for drug delivery, this book, published in cooperation with the University of Michigan College of Pharmacy, is a peer-reviewed introductory physical pharmacy and biopharmaceutics text that comprehensively addresses the major issues in the field of Pharmacy Practice. It is a must for students wishing to understand the background and mechanics of dosage form technology.
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The Poisonous Pen of Agatha Christie
By Michael C. Gerald
University of Texas Press, 1993
Library of Congress PR6005.H66Z653 1993 | Dewey Decimal 823.912
Poisoning occurs in over half of Agatha Christie's many novels and stories. In fact, she used a larger number and broader selection of poisons and medicines, for a wider variety of purposes, with greater frequency, ingenuity, and scientific accuracy than any other detective fiction writer. Yet very little has been written on the use of drugs, poisons, and chemicals in Christie's fiction.
The Poisonous Pen of Agatha Christie entertainingly and authoritatively fills this gap. Michael Gerald explores the use of poisons and drugs in Christie's fiction not only to commit murder and suicide but also to incapacitate a victim, alter behavior, treat disease, or support addiction. He also analyzes her views, as expressed in her fiction and autobiography, on drug addiction, the health professions, the value of medicines, and scientific discoveries.
Especially valuable is Gerald's exhaustive listing of all drugs, poisons, and chemicals mentioned in Christie's novels and stories, with references to the work(s) in which each appears and the ways in which each is used. Other tables list all the novels and short stories and the chemicals that are used in each. Throughout, the properties of all drugs are clearly explained so that the reader needs no special scientific or medical knowledge.
The Poisonous Pen of Agatha Christie illuminates the fictional uses Christie made of her real-life experiences as a hospital drug dispenser and as a provider of nursing care. It will be of interest to fans and scholars alike.
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Synthesizing Hope: Matter, Knowledge, and Place in South African Drug Discovery
Anne Pollock
University of Chicago Press, 2019
Library of Congress HD9673.S64I74 2019 | Dewey Decimal 338.76161510968
Synthesizing Hope opens up the material and social world of pharmaceuticals by focusing on an unexpected place: iThemba Pharmaceuticals. Founded in 2009 with a name taken from the Zulu word for hope, the small South African startup with an elite international scientific board was tasked with drug discovery for tuberculosis, HIV, and malaria. Anne Pollock uses this company as an entry point for exploring how the location of scientific knowledge production matters, not only for the raw materials, manufacture, licensing, and distribution of pharmaceuticals but also for the making of basic scientific knowledge.
Consideration of this case exposes the limitations of global health frameworks that implicitly posit rich countries as the only sites of knowledge production. Analysis of iThemba identifies the problems inherent in global north/south divides at the same time as it highlights what is at stake in who makes knowledge and where. It also provides a concrete example for consideration of the contexts and practices of postcolonial science, its constraints, and its promise.
Synthesizing Hope explores the many legacies that create conditions of possibility for South African drug discovery, especially the specific form of settler colonialism characterized by apartheid and resource extraction. Paying attention to the infrastructures and laboratory processes of drug discovery underscores the materiality of pharmaceuticals from the perspective of their makers, and tracing the intellectual and material infrastructures of South African drug discovery contributes new insights about larger social, political, and economic orders.
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Technopharmacology
Joshua Neves
University of Minnesota Press, 2022
Library of Congress RS56.7.N48 2022 | Dewey Decimal 615.1
Exploring networked technologies and bioeconomy and their links to biotechnologies, pharmacology, and pharmaceuticals
Being on social media, having pornography or an internet addiction, consciousness hacking, and mundane smartness initiatives are practices embodied in a similar manner to the swallowing of a pill. Such close relations of media technologies to pharmaceuticals and pharmacology is the focus of this book. Technopharmacology is a modest call to expand media theoretical inquiry by attending to the biological, neurological, and pharmacological dimensions of media and centers on emergent affinities between big data and big pharma.
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Therapeutic Revolutions: Pharmaceuticals and Social Change in the Twentieth Century
Edited by Jeremy A. Greene, Flurin Condrau, and Elizabeth Siegel Watkins
University of Chicago Press, 2016
Library of Congress HD9665.5.T46 2016 | Dewey Decimal 303.483
When asked to compare the practice of medicine today to that of a hundred years ago, most people will respond with a story of therapeutic revolution: Back then we had few effective remedies, but now we have more (and more powerful) tools to fight disease, from antibiotics to psychotropics to steroids to anticancer agents.
This collection challenges the historical accuracy of this revolutionary narrative and offers instead a more nuanced account of the process of therapeutic innovation and the relationships between the development of medicines and social change. These assembled histories and ethnographies span three continents and use the lived experiences of physicians and patients, consumers and providers, and marketers and regulators to reveal the tensions between universal claims of therapeutic knowledge and the actual ways these claims have been used and understood in specific sites, from postwar West Germany pharmacies to twenty-first century Nigerian street markets. By asking us to rethink a story we thought we knew, Therapeutic Revolutions offers invaluable insights to historians, anthropologists, and social scientists of medicine.
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White Market Drugs: Big Pharma and the Hidden History of Addiction in America
David Herzberg
University of Chicago Press, 2020
Library of Congress RA401.A3H47 2020 | Dewey Decimal 362.1782
The contemporary opioid crisis is widely seen as new and unprecedented. Not so. It is merely the latest in a long series of drug crises stretching back over a century. In White Market Drugs, David Herzberg explores these crises and the drugs that fueled them, from Bayer’s Heroin to Purdue’s OxyContin and all the drugs in between: barbiturate “goof balls,” amphetamine “thrill pills,” the “love drug” Quaalude, and more. As Herzberg argues, the vast majority of American experiences with drugs and addiction have taken place within what he calls “white markets,” where legal drugs called medicines are sold to a largely white clientele.
These markets are widely acknowledged but no one has explained how they became so central to the medical system in a nation famous for its “drug wars”—until now. Drawing from federal, state, industry, and medical archives alongside a wealth of published sources, Herzberg re-connects America’s divided drug history, telling the whole story for the first time. He reveals that the driving question for policymakers has never been how to prohibit the use of addictive drugs, but how to ensure their availability in medical contexts, where profitability often outweighs public safety. Access to white markets was thus a double-edged sword for socially privileged consumers, even as communities of color faced exclusion and punitive drug prohibition. To counter this no-win setup, Herzberg advocates for a consumer protection approach that robustly regulates all drug markets to minimize risks while maintaining safe, reliable access (and treatment) for people with addiction.
Accomplishing this requires rethinking a drug/medicine divide born a century ago that, unlike most policies of that racially segregated era, has somehow survived relatively unscathed into the twenty-first century.
By showing how the twenty-first-century opioid crisis is only the most recent in a long history of similar crises of addiction to pharmaceuticals, Herzberg forces us to rethink our most basic ideas about drug policy and addiction itself—ideas that have been failing us catastrophically for over a century.
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