When the brain suffers an injury, the effects can be delayed and unpredictable. Cerebrospinal fluid can slowly build up, causing dangerously high levels of intracranial pressure (ICP), and the brain tissue can be displaced into adjacent compartments, resulting in cerebral herniation syndrome (CHS). Within the burgeoning field of neurocritical care, experts are just beginning to understand the nuanced, sometimes counterintuitive relationship between ICP and CHS.  

 

Written by leading researchers who also have extensive first-hand clinical experience treating brain injury patients, Cerebral Herniation Syndromes and Intracranial Hypertension provides an up-to-date guide to this complex aspect of neurocritical care. Drawing from expertise gained working in high-volume medical centers, the book’s contributors reveal that there is no universal metric for gauging acceptable levels of intracranial pressure. Instead, they demonstrate the best practices for offering patients individualized care, based on their specific conditions and manifest symptoms.  
 

Bringing together internationally-renowned neurocritical care experts from a variety of neurology, critical care, surgery, and neurosurgery disciplines, this volume takes a comprehensive look at a complicated issue. A concise, practical, and timely review, Cerebral Herniation Syndromes and Intracranial Hypertension offers vital information for all medical personnel concerned with improving neurocritical patient care.  

 

This brief, clinically-focused volume is informed by Lawrence I. Golbe’s three decades of research and tertiary clinical care in progressive supranuclear palsy, a complex disorder with rapidly changing diagnostic and therapeutic approaches. It is an ideal source for the general neurologist seeking a refresher and the primary care provider, neurological nurse, or physical, occupational or speech therapist who must address their patients’ specialized needs.
 
A Clinician’s Guide to Progressive Supranuclear Palsy emphasizes early diagnostic signs, medication options, non-pharmacologic management and palliative care. It offers a quick overview of the complications of PSP most likely to prompt an ER visit; a widening spectrum of PSP variants; and ample description of the genetics, epidemiology, natural history, pathology, molecular biology and neurochemistry of PSP. The PSP Rating Scale used in the book is a convenient tool for clinicians in routine practice and the leading PSP clinical measure world-wide. Golbe provides a practical and useful guidebook to help all clinicians learn and battle this complex disorder.
 

Neurofilaments was first published in 1983. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.

Neurofilaments are fibrous organelles that serve as one of the main structural elements of neurons. Synthesized in the perikaryon ,or nerve cell body, neurofilaments are transported along the axon, where they help to maintain the neuronal architecture. Recent research has shown that neurofilaments are biochemically distinct from other kinds of cellular filaments and that they play a special role in the health and functioning of neurons. Although their existence has been recognized for over a century, scientists have only recently started to apply the methods of cellular and molecular biology to the study of neurofilaments, aided by the use of the electron microscope. The study of neurofilaments has raised a number of interesting biological questions with implications for our understanding of neurophysiology, neuroanatomy, and neurology. This book is the first to provide, in one place, reports by specialists on the most significant areas of research on these neuronal organelles.

The book opens with a historical background to current research, followed by chapters dealing with the neuronal cytoskeleton; the biochemistry of neurofilaments; neurofilaments of the mammalian peripheral nerve; the functional role of neurofilaments in axonal transport; the metabolism of neurofilaments; experimental models of abnormal neurofilamentous pathology; and the relation of these abnormal structures to Alzheimer's disease. Editor Charles Marotta's closing chapter surveys current and future neurofilament research.

The field of research related to neurocritical care has grown significantly in recent years, and the clinical demands for current and dependable expertise has followed suit. It can be a challenge for the neurocritical practitioner to keep up with cutting-edge evidence-based research and best practices, especially regarding the role of pharmacotherapeutics. 

In the treatment of neurocritical disease states, pharmacotherapeutic strategies are increasingly relevant. Neuropharmacotherapy in Critical Illness is the first book that provides this information in a high-yield format for the busy healthcare provider. Edited and authored by leading experts in the field, this book provides practitioners with clinical pearls on neuropharmacology, dosing strategies, monitoring, adverse events, drug interactions, and evidence-based pharmacotherapy.   
 

Physiological Foundations of Neurology and Psychiatry was first published in 1953.The findings of Dr. Gellhorn’s extensive and significant research on the physiology of the central nervous system form the basis of the discussion in this volume. Reference is frequently made to the applicability of this laboratory experience to clinical as well as other fields. An attempt has been made to integrate the clinical and experimental literature with the discussion, to give an up-to-date picture of the problems involved and to indicate the possibilities for future investigation. Topics of interest to physiologists, endocrinologists, internists, neurologists and neurosurgeons, psychiatrists, and clinical psychologists are discussed.An important aspect of the author’s work concerned certain recent tests which show an altered reactivity of autonomic centers in the psychotic condition. His interpretation of the significance of these tests for a physiologically oriented therapy of functional psychoses is published here for the first time. The physiological effects actually produced in the central nervous system by “shock” treatment and carbon dioxide therapy are analyzed.Other sections give consideration to some of the principal working mechanisms of the neuron, to the factors determining movements and convulsions, to the pathophysiology of cortical lesions, to some aspects of autonomic physiology, and to the problem of consciousness. An important section deals with integrative functions of the nervous system - those involved in emotion, the conditioning process as the basis of behavior, and homeostasis.

The Physiology and Pathology of the Cerebellum was first published in 1958. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.

The development of electrical methods of recording activity in the nervous system has greatly augmented our knowledge of cerebellar physiology. Now, for the first time in a single volume, this new information has been related to facts derived from older methods of investigation. Previously unpublished reports of experiments conducted at the Institute of Physiology, University of Pisa, Italy, also are included.

The authors, an American clinical neurologist and an Italian neuro-physiologist, have collaborated to provide a comprehensive review of cerebellar physiology and a survey of the clinical symptomatology of cerebellar disorders and the pathology of the cerebellum.

In Part I, devoted to the physiology, the authors review the literature completely and place it in proper relation to the latest developments in this field. There are chapters on this history of cerebellar physiology, ablation experiments, stimulation experiments, electro-physiological experiments, the relations between the cerebellum and other central nervous structures, developmental physiology, and the functions of the cerebellum, considered generally.

Part II is devoted to the human cerebellum as studied in the clinic. Where anatomical and physiological observation may shed light upon obscure clinical findings, the laboratory data are related to the clinical investigations. The disorders and diseases affecting the cerebellum are systemically reviewed. The book is illustrated with 61 halftones and 124 line drawings.

“Shapes of Memory Loss” is a collection of poetry, fiction, and narrative written by and about people with cognitive impairment or dementia. The authors, all affiliated with the University of Michigan Health System, come forward to share their personal experience as they “navigate this unknown territory”. These pieces offer the reader a view into the often isolated and not fully understood journey that those with memory loss and cognitive impairment are on. The book serves as an educational and support tool for anyone who has been touched by dementia, memory loss, and other related disorders. Healthcare professionals will gain information and insight about these disorders presented from the perspective of patients and families affected by them.

Even in this information age, it is a daunting task to find clear, concise, and credible sources for essential medical facts. And for those dealing with the symptoms of often serious neurological disorders, finding trustworthy and straightforward information is gravely important.

Treating the Brain is precisely what has been missing for non-specialists. Focusing on the most common neurological conditions, it provides accurate, reliable information to patients, caregivers, and health practitioners from the neurologist whose professional text informs neurologists worldwide.. Walter G. Bradley, one of the nation’s foremost neurologists and the editor of the leading neurology textbook Neurology in Clinical Practice, navigates the complexities of the brain in highly accessible language. Treating the Brain is the definitive resource for patients, offering a coherent and up-to-date understanding of what physicians know about the brain. In the United States alone, one-quarter of all new consultations between patients and their family physician is a result of a neurological problem. Using case histories as examples, Treating the Brain explains the neurological examinations and tests and clinical features, causes, and treatments available for Alzheimer’s disease, migraines, stroke, epilepsy, Parkinson’s and other frequently diagnosed neurological disorders.

For anyone who has ever had a neurological symptom, from a headache to tingling hands, and for anyone with a personal interest in how the brain works in health and disease, Treating the Brain will prove to be a valuable, easy-to-read source of a wide-range of information.