Taking us to the cutting edge of the new frontier of medicine, a visionary biotechnologist and a pathbreaking researcher show how we can optimize our health in ways that were previously unimaginable.

We are on the cusp of a major transformation in healthcare—yet few people know it. At top hospitals and a few innovative health-tech startups, scientists are working closely with patients to dramatically extend their “healthspan”—the number of healthy years before disease sets in. In The Age of Scientific Wellness, two visionary leaders of this revolution in health take us on a thrilling journey to this new frontier of medicine.

Today, most doctors wait for clinical symptoms to appear before they act, and the ten most commonly prescribed medications confer little or no benefit to most people taking them. Leroy Hood and Nathan Price argue that we must move beyond this reactive, hit-or-miss approach to usher in real precision health—a form of highly personalized care they call “scientific wellness.” Using information gleaned from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. Current applications have shown startling results: diabetes reversed, cancers eliminated, Alzheimer’s avoided, autoimmune conditions kept at bay.

This is not a future fantasy: it is already happening, but only for a few patients and at high cost. It’s time to make this gold standard of care more widely available. Inspiring in its possibilities, radical in its conclusions, The Age of Scientific Wellness shares actionable insights to help you chart a course to a longer, healthier, and more fulfilling life.

Over the course of human history, the sciences, and biology in particular, have often been manipulated to cause immense human suffering. For example, biology has been used to justify eugenic programs, forced sterilization, human experimentation, and death camps—all in an attempt to support notions of racial superiority. By investigating the past, the contributors to Biology and Ideology from Descartes to Dawkins hope to better prepare us to discern ideological abuse of science when it occurs in the future.  

Denis R. Alexander and Ronald L. Numbers bring together fourteen experts to examine the varied ways science has been used and abused for nonscientific purposes from the fifteenth century to the present day. Featuring an essay on eugenics from Edward J. Larson and an examination of the progress of evolution by Michael J. Ruse, Biology and Ideology examines uses both benign and sinister, ultimately reminding us that ideological extrapolation continues today. An accessible survey, this collection will enlighten historians of science, their students, practicing scientists, and anyone interested in the relationship between science and culture.

Scientific breakthroughs have led us to a point where soon we will be able to make specific choices about the genetic makeup of our offspring. In fact, this reality has arrived—and it is only a matter of time before the technology becomes widespread.

Much like past arguments about stem-cell research, the coming debate over these reproductive genetic technologies (RGTs) will be both political and, for many people, religious. In order to understand how the debate will play out in the United States, John H. Evans conducted the first in-depth study of the claims made about RGTs by religious people from across the political spectrum, and Contested Reproduction is the stimulating result.

Some of the opinions Evans documents are familiar, but others—such as the idea that certain genetic conditions produce a “meaningful suffering” that is, ultimately, desirable—provide a fascinating glimpse of religious reactions to cutting-edge science. Not surprisingly, Evans discovers that for many people opinion on the issue closely relates to their feelings about abortion, but he also finds a shared moral language that offers a way around the unproductive polarization of the abortion debate and other culture-war concerns. Admirably evenhanded, Contested Reproduction is a prescient, profound look into the future of a hot-button issue.

A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny?

Drosophila’s importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases.

Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these “first in fly” findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.

They mastermind our lives, shaping our features, our health, and our behavior, even in the sacrosanct realms of love and sex, religion, aging, and death. Yet we are the ones who house, perpetuate, and give the promise of immortality to these biological agents, our genetic gods. The link between genes and gods is hardly arbitrary, as the distinguished evolutionary geneticist John Avise reveals in this compelling book. In clear, straightforward terms, Avise reviews recent discoveries in molecular biology, evolutionary genetics, and human genetic engineering, and discusses the relevance of these findings to issues of ultimate concern traditionally reserved for mythology, theology, and religious faith.

The book explains how the genetic gods figure in our development--not just our metabolism and physiology, but even our emotional disposition, personality, ethical leanings, and, indeed, religiosity. Yet genes are physical rather than metaphysical entities. Having arisen via an amoral evolutionary process--natural selection--genes have no consciousness, no sentient code of conduct, no reflective concern about the consequences of their actions. It is Avise's contention that current genetic knowledge can inform our attempts to answer typically religious questions--about origins, fate, and meaning. The Genetic Gods challenges us to make the necessary connection between what we know, what we believe, and what we embody.

The secrets locked in our genes are being revealed, and we find ourselves both enthused and frightened about what that portends. We look forward to curing disease and alleviating suffering—for our children as well as for ourselves—but we also worry about delving too deeply into the double helix. Abuses perpetrated by eugenicists—from involuntary sterilization to murder—continue to taint our feelings about genetic screening.

Yet, as Ruth Schwartz Cowan reveals, modern genetic screening has been practiced since 1960, benefiting millions of women and children all over the world. She persuasively argues that new forms of screening—prenatal, newborn, and carrier testing—are both morally right and politically acceptable. Medical genetics, built on the desire of parents and physicians to reduce suffering and increase personal freedom, not on the desire to “improve the human race,” is in fact an entirely different enterprise from eugenics.

Cowan’s narrative moves from an account of the interwoven histories of genetics and eugenics in the first half of the twentieth century, to the development of new forms of genetic screening after mid-century. It includes illuminating chapters on the often misunderstood testing programs for sickle cell anemia, and on the world’s only mandated premarital screening programs, both of them on the island of Cyprus.

Neither minimizing the difficulty of the choices that modern genetics has created for us nor fearing them, Cowan bravely and compassionately argues that we can improve the quality of our own lives and the lives of our children by using the modern science and technology of genetic screening responsibly.

The mystery of inheritance has captivated thinkers since antiquity, and the unlocking of this mystery—the development of classical genetics—is one of humanity’s greatest achievements. This great scientific and human drama is the story told fully and for the first time in this book.

Acclaimed science writer James Schwartz presents the history of genetics through the eyes of a dozen or so central players, beginning with Charles Darwin and ending with Nobel laureate Hermann J. Muller. In tracing the emerging idea of the gene, Schwartz deconstructs many often-told stories that were meant to reflect glory on the participants and finds that the “official” version of discovery often hides a far more complex and illuminating narrative. The discovery of the structure of DNA and the more recent advances in genome science represent the culmination of one hundred years of concentrated inquiry into the nature of the gene. Schwartz’s multifaceted training as a mathematician, geneticist, and writer enables him to provide a remarkably lucid account of the development of the central ideas about heredity, and at the same time bring to life the brilliant and often eccentric individuals who shaped these ideas.

In the spirit of the late Stephen Jay Gould, this book offers a thoroughly engaging story about one of the oldest and most controversial fields of scientific inquiry. It offers readers the background they need to understand the latest findings in genetics and those still to come in the search for the genetic basis of complex diseases and traits.

“In this rigorous and beautifully researched volume, Milanich considers the tension between social and biological definitions of fatherhood, and shows how much we still have to learn about what constitutes a father.”
—Andrew Solomon, author of Far from the Tree: Parents, Children, and the Search for Identity

For most of human history, the notion that paternity was uncertain appeared to be an immutable law of nature. The unknown father provided entertaining plotlines from Shakespeare to the Victorian novelists and lay at the heart of inheritance and child support disputes. But in the 1920s new scientific advances promised to solve the mystery of paternity once and for all. The stakes were high: fatherhood has always been a public relationship as well as a private one. It confers not only patrimony and legitimacy but also a name, nationality, and identity.

The new science of paternity, with methods such as blood typing, fingerprinting, and facial analysis, would bring clarity to the conundrum of fatherhood—or so it appeared. Suddenly, it would be possible to establish family relationships, expose adulterous affairs, locate errant fathers, unravel baby mix-ups, and discover one’s true race and ethnicity. Tracing the scientific quest for the father up to the present, with the advent of seemingly foolproof DNA analysis, Nara Milanich shows that the effort to establish biological truth has not ended the quest for the father. Rather, scientific certainty has revealed the fundamentally social, cultural, and political nature of paternity. As Paternity shows, in the age of modern genetics the answer to the question “Who’s your father?” remains as complicated as ever.

Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The Society of Genes now provides a vision of how genes cooperate and compete in the struggle for life.

Pioneers in the nascent field of systems biology, Itai Yanai and Martin Lercher present a compelling new framework to understand how the human genome evolved and why understanding the interactions among our genes shifts the basic paradigm of modern biology. Contrary to what Dawkins’s popular metaphor seems to imply, the genome is not made of individual genes that focus solely on their own survival. Instead, our genomes comprise a society of genes which, like human societies, is composed of members that form alliances and rivalries.

In language accessible to lay readers, The Society of Genes uncovers genetic strategies of cooperation and competition at biological scales ranging from individual cells to entire species. It captures the way the genome works in cancer cells and Neanderthals, in sexual reproduction and the origin of life, always underscoring one critical point: that only by putting the interactions among genes at center stage can we appreciate the logic of life.