In Chains of Babylon, Daryl J. Maeda presents a cultural history of Asian American activism in the late 1960s and early 1970s, showing how the movement created the category of "Asian American" to join Asians of many ethnicities in racial solidarity. Drawing on the Black Power and antiwar movements, Asian American radicals argued that all Asians in the United States should resist assimilation and band together to oppose racism within the country and imperialism abroad.

As revealed in Maeda's in-depth work, the Asian American movement contended that people of all Asian ethnicities in the United States shared a common relationship to oppression and exploitation with each other and with other nonwhite peoples. In the early stages of the civil rights era, the possibility of assimilation was held out to Asian Americans under a model minority myth. Maeda insists that it was only in the disruption of that myth for both African Americans and Asian Americans in the 1960s and 1970s that the full Asian American culture and movement he describes could emerge. Maeda challenges accounts of the post-1968 era as hopelessly divisive by examining how racial and cultural identity enabled Asian Americans to see eye-to-eye with and support other groups of color in their campaigns for social justice.

Asian American opposition to the war in Vietnam, unlike that of the broader antiwar movement, was predicated on understanding it as a racial, specifically anti-Asian genocide. Throughout he argues that cultural critiques of racism and imperialism, the twin "chains of Babylon" of the title, informed the construction of a multiethnic Asian American identity committed to interracial and transnational solidarity.

The current image of the Spanish conquest of America and of the conquistadores who carried it out is one of destruction and oppression. One conquistador does not fit that image, however. A life-changing adventure led Cabeza de Vaca to seek a different kind of conquest, one that would be just and humane, true to Spanish religion and law, but one that safeguarded liberty and justice for the Indians of the New World. His use of the skills learned from his experiences with the Indians of North America did not always help him in understanding and managing the Indians of South America, and too many of the Spanish settlers in the Rio de la Plata Province found that his policies threatened their own interests and relations with the Indians. Eventually many of those Spaniards joined a conspiracy that removed him from power and returned him to Spain in chains.

That Cabeza de Vaca was overthrown is not surprising. His ideas and policies opposed the self-interest of most of the first Spaniards who had come to America. What is amazing is that he was able to inspire and hold support among many others in America, who remained loyal to him during his time in prison and after his return to Spain.